Professor Clive Prestidge
Contact Details
Tel: +61 8 8302 3569
Fax: +61 8 8302 3683
Email: clive.prestidge@unisa.edu.au
Position
Associate Director: Nanomedicine
Research Professor of Colloid and Pharmaceutical Science
Qualifications
BSc(Hons) Loughborough, UK PhD Bristol, UK
Background
Clive Prestidge is a physical chemist who specialises in fundamental and applied aspects of colloid and interface science. Clive's PhD from Bristol University was concerned with polymers at interfaces, in particular the application of FTIR to determine adsorbed polymer conformations. He joined the University of South Australia in 1990 as a post-doctoral fellow to investigate the colloid and surface properties of minerals, particularly applications to sulphide mineral flotation and alumina crystallization. During the late 90's Clive developed a strong interest in the application of colloid and interfacial chemistry to pharmaceutical delivery systems and has subsequently developed this area within the Ian Wark Research Institute and through a number of national and international collaborations.
Clive is currently a Research Professor and Associate Director:
Nanomediciene at The Wark and leads research teams with a primary focus on nano-structured
drug delivery systems and interfacial science applied to pharmaceutical
formulation and delivery.
Clive is the author of over 100 refereed international journal articles, textbook chapters and conference papers and over 80 major project reports to industry. He has supervised 18 PhD, 5 MSc and 19 Honours students and has taken a leadership role in a number of major collaborative projects in association with national and international industries, the ARC, and University researchers from Australia and overseas.
Prof Prestidge has attracted competitive research grants worth more than $5.1M from government and industry sources.
Research Interests
-
Interfacial chemistry of colloidal systems and colloidal interactions
- Particle and polymer adsorption at solid and liquid interfaces
- Rheology of suspensions, polymer solutions, emulsions and foams
- Droplet interactions, emulsion stability and emulsion processing
- Colloidal drug delivery
- Solid state pharmaceutics
- Nanostructured materials as pharmaceutical delivery systems, eg.:
dendrimers, porous silicon and nanoparticles for encapsulation
Supervisor - Available Postgraduate/Honours Projects
A
physicochemical approach for optimizing drug delivery from biosiliconTM
(P)
Dielectric
properties and biological interactions of ultrathin polymeric coatings
(P)
Interfacial properties of biological cells: Structure, deformation and
interactions (P)
Interfacial properties of dendrimers for improved pharmaceutical activity
(P)
Nanoparticle coatings for improved pharmaceutical delivery (P)
Nanoparticle liquid crystal hybrids: Physicochemical and biopharmaceutical
investigations (P)
Novel methods for
the development and manufacture of pharmaceutical nanoparticles (P)
A physicochemical approach for optimizing drug delivery from
biosiliconTM
(H)
Dielectric properties and biological interactions of ultrathin polymeric
coatings (H)
Interfacial properties of dendrimers for improved pharmaceutical activity
(H)
Nanoparticle coatings for improved pharmaceutical delivery (H)
Novel methods for
the development of pharmaceutical nanoparticles (H)
Current Projects
Droplet deformation, droplet Interaction, emulsion stability and emulsion rheology (ARC SRC program)
Physico-chemical and biopharmaceutical investigations on novel drug delivery systems for oral administration of lipophilic drugs (ARC Discovery)
A physicochemical approach for optimising drug delivery from BiosiliconTM (ARC Linkage)
Interfacial studies of nanoparticulate dendrimers for improved biopharmaceutical application (ARC Linkage)
Improved oral delivery of poorly soluble drugs using nanoparticle encapsulation technologies
A novel liposome encapsulation method for protein delivery
Nanoparticulate encapsulation for new and improved cosmeceuticals
Feasibility study for evaluation of peptide binding and release from biosiliconTM
Interfacial modification for improved liposomal delivery
Deformation and interaction of blood cells & blood rheology
Centre for advanced pharmaceutical formulation, characterisation and manufacture
Innovative Centre for Drug Formulation and Delivery (SA Govt Science and Technology Initiative)
Publications
Book Chapters
1. C.A. Prestidge, 'From Novel Monodisperse Silicone Oil"/Water Emulsions
to Drug Delivery', in "New Frontiers in Colloid Science", S. Biggs, T.
Cosgrove and Peter Dowding (Eds), Royal Society of Chemistry, 2008, pp.
70-89.
2. J. Addai-Mensah, C.A. Prestidge, "Structure Formation in Dispersed
Systems", in Coagulation and Flocculation (Surfactant Science Series) 2nd
Edition, GB H. Stechemesser and B. Dobias, 2005 volume 126, p. 135-216.
3. St.C. Smart, J. Aramantides, W.M. Skinner, C.A. Prestidge, L. La Vanier
and S.R. Grano, Surface Analytical Studies of Oxidation and Collector
Adsorption in Sulfide Mineral Flotation, K. Wandelt, S. Thurgate (Eds.):
Solid-Liquid Interfaces, Topics Appl. Phys. 85, 3-60 (2003) Springer-Verlag,
Berlin Heidelberg.
4. C.A. Prestidge, J. Ralston and R.St.C. Smart, The Actions of Cyanide in
the Flotation Separation of Base-Metal Sulphides. In "Innovations in Mineral
Processing", T. Yalcin (ed.), ACME printers, Sudbury, Ontario, (1994)
pp.67-97.
5. R.St.C. Smart, P. Arora, R.A, Hayes, B.S. Kim, C.A. Prestidge and J.
Ralston, Chemical and Structural Alterations in the Surface Layers of Oxides
and Sulphides, in "Science of Ceramic Interfaces II" (Ed. J. Nowotny),
Materials Science Monographs, Elsevier (Amsterdam), pp. 311-340 (1994).
Recent Refereed Journal Articles
2011
1. Yao-Da Dong, I. Larson, T. Barnes, C.A. Prestidge, B. Boyd
"Adsorption of non-lamellar nanostructured liquid crystalline particles to
bio-relevant surfaces for improved delivery of bioactive compounds" ACS
Applied Materials & Interfaces 3(5) 1771-1780, 2011.
2. M. D. Kurkuri, F. Al-Ejeh, Jun Yan Shi, D. Palms, C. A. Prestidge, H. J.
Griesser, M. P. Brown and B. Thierry, "Plasma functionalized PDMS
microfluidic chips: towards point-of-care capture of circulating tumor
cells", Journal of Materials Chemistry, 21, 8841-8848, 2011
3.
S. Simovic, N. Ghouchi Eskandar, M.S. Aw, D. Losic and C.A. Prestidge,
"Silica Materials in Drug Delivery Applications", Current Drug Discovery
Technologies, 8 (3), 250-268, 2011
4.
Li Hui Lim, A. Tan, S. Simovic, C.A. Prestidge, "Silica-lipid hybrid
microcapsules: Influence of lipid and emulsifier type on in vitro
performance", Int J. Pharmaceutics, 409 297-306, 2011
5.
A. Tan, A.K. Davey, C.A. Prestidge, "Silica-lipid hybrid (SLH) versus
non-lipid formulations for optimising the dose-dependent oral absorption of
celecoxib", Pharmaceutical Research, 28 2273-2287 2011
6.
N. Ghouchi Eskandar, S. Simovic and C. A. Prestidge, "Interactions of
hydrophilic silica nanoparticles and classical surfactants at non-polar
oil-water interface", J. Colloid Interface Science , 358, 217-225, 2011.
7.
S. Simovic, N. Ghouchi Eskandar, C. A. Prestidge, "Pickering emulsions for
dermal delivery", J. Drug Delivery Science and Technology 21(1), 123-133,
2011.
8.
Timothy J. Barnes, Ivan M. Kempson, C. A. Prestidge, "Surface analysis for
compositional, chemical and structural imaging in pharmaceutics with mass
spectrometry: A ToF-SIMS perspective", Int J. Pharmaceutics, 417, 61-69,
2011.
2010
9.
Kempson, A. Martin, J. Denman, P. French, C.A. Prestidge, T. Barnes,
"Detecting the presence of Denatured Human Serum Albumin in an Adsorbed
Protein Monolayer using TOF-SIMS", Langmuir , 26(14), 12075-12080, 2010.
10. K. Jarvis, T. Barnes and C.A. Prestidge, "Thermal oxidation for
controlling Protein Interaction with Porous Silicon" Langmuir, 2010, 26(17),
14316-14322.
11.
S. Parimi, T. Barnes, D. Callen, C.A. Prestidge, "Mechanistic Insight into
Cell Growth, Internalization, and Cytotoxicity of PAMAM Dendrimers", Biomacromolecules, 11, 382-389, 2010.
12.
V.J. Mohanraj, T.J. Barnes, C.A. Prestidge, "Silica Nanoparticle Coated
Liposomes: A New Type of Hybrid Nanocapsule for Proteins", Int J.
Pharmaceutics, 392, 285-293, 2010.
13. A. Tan, S. Simovic, A.K. Davey, B. Boyd, T. Rades, C.A. Prestidge,
"Silica Nanoparticles to Control the Lipase-Mediated Digestion of
Lipid-Based Oral Delivery Systems", Molecular Pharmaceutics, 7, 522-532,
2010.
14. A.K. Panda, K. Vasilev, S. Orgeig, C.A. Prestidge, "Thermodynamic and
structural studies of mixed monolayers: mutual mixing of DPPC and DPPG with
DoTAP at the air-water interface", Materials Science & Engineering C., 30,
542-548, 2010.
15. F. Wang, H. Hui, T.J. Barnes, C. Barnett and C.A. Prestidge, "Oxidized Mesoporous Silicon Microparticles for Improved Oral Delivery of Poorly
Soluble Drugs", Molecular Pharmaceutics, 7, 227- 236, 2010.
16. S. Simovic, P. Heard, H. Hui, Y. Song, A. Davey, T. Rades, C.A.
Prestidge "An oral delivery system for Indomethicin engineered from cationic
lipid emulsions and silica nanoparticles" Journal of Controlled Release,
143, 367-373, 2010.
17. S. Simovic, P. Heard, C. A. Prestidge, "Hybrid lipid-silica
microcapsules engineered by phase coacervation of Pickering emulsions",
Physical Chemistry and Chemical Physics, 12, 7162-7170, 2010.
18. I. Kempson, T. Barnes and C.A. Prestidge, "Use of ToF-SIMS to study
adsorption and loading behaviour of methylene blue and papain in a porous
silicon layer", Journal of the American Society for Mass Spectrometry., 21,
254-260, 2010
19. N. Ghouchi Eskandar, S. Simovic and C. A. Prestidge, "Mechanistic
insight into the dermal delivery from nanoparticle-coated submicron O/W
emulsions", J. Pharmaceutical Sci, 99: 890-904, 2010
Full List (PDF 32kb)