Ian Wark Research Institute
ARC Special Research Centre
ARC Special Research Centre
Research Area: Biotechnology
Supervisors:
Prof Clive Prestidge and
Dr Angel Tan
Description: Several obstacles remain for oral delivery of
protein and anticancer therapeutics in vivo, such as physical barriers
to prevent adequate absorption, or uncontrolled or nonspecific delivery
of drugs. In particular, oral delivery of anticancer and protein
therapeutics presents a unique set of obstacles, such as low drug
permeability through gastrointestinal epithelium and limited drug
retention at the epithelial interface. In dermal and transdermal
applications of therapeutics drug protection and enhanced penetration
and targeting are required.
This project will be focused on the formation of new type of
pharmaceutical emulsions fabricated from biocompatible nanoparticles and
microcapsules with advanced drug delivery features. In particular, the
feasibility to design and fabricate novel emulsions and microcapsules
will be investigated, and key characteristics and processes involved in
in vitro drug delivery will be exploited.
