The Mechanisms in Cell Biology and Disease Research Group has a specific interest in endosome-lysosome cell biology in cancer and is developing diagnostic, prognostic and imaging technology for biochemical medicine, which will benefit patients and the wider community.
Other research predominantly aims to understand the underlying molecular mechanisms contributing to neuropathology and respiratory dysfunction in lysosomal storage disorders. Determining the link between lysosomal storage and altered secretion, will allow us to gain insight into important cellular mechanisms that will yield targets for future therapeutic intervention.
This research group is currently developing diagnostic and prognostic biomarkers for prostate cancer and establishing the efficacy of this technology through clinical trials. We are also developing novel molecular probes that can be used to visualise lipids, sugars and endocytosis; and that can be adapted as diagnostic and prognostic tools for prostate cancer and other cancer imaging. We also have a project on the role of inflammation in prostate cancer and other immune disorders.
Read more about our current research
Cell Biology, confocal microscopy, live cell imaging, in vitro cell models, immunochemistry, ELISA, histology, molecular biology, protein biophysics, chemistry, synthesis, imaging agents.
Emma Parkinson-Lawrence manages the Biophysical Characterisation Facility which houses state of the art equipment for bio-molecular interactions including a BiacoreT200 and Jasco Circular Dichroism Spectrometer.