Genetics and Genomics

Epilepsy

Genetics is the study of single genes or groups of genes and how their traits are inherited between generations. By studying the patterns of inheritance of a particular disease trait/phenotype we are able to identify which gene, or genes, are responsible for causing the disease. Genomics is the study of the entire genome or all of the genes of an organism and has been greatly advanced by the development of new Next Generation DNA Sequencing technologies which enable us to sequence the entire genome of a person or organism very quickly and relatively cheaply. By combining Genetic and Genomics analyses we have a very powerful tool that allows us to identify the genes that cause a range of diseases.

Our research

Molecular Neurogenomics Group

Specialising in the studying the genetic basis of Neurological and Behavioural disorders in particular Epilepsy and its associated comorbidities and Neuromuscular disorders.

Pharmacogenetics / Pharmacogenomics research

These researchers study how the genetic makeup of an individual affects his/her response to drugs. Such research involves identifying genetic markers for both treatment response as well as adverse drug reactions in various diseases. The implications of these projects will revolutionise the way doctors prescribe drugs for their patients.

Our capabilities

We conduct; Molecular genetic analyses of Patient DNA, Whole Genome and Whole Exome Sequencing, Targeted Resequencing, Transcriptome Sequencing and associated Bioinformatics and statistical analyses of DNA sequence data, Sanger DNA Sequencing validation, High Resolution Melt Curve Analyses, Molecular Cloning and Transgenesis, Immunohistochemical analyses and Confocal Microscopy, Protein analyses.

Areas of study and research

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