Host-guest interaction

Research area: Materials science, biotechnology
Degree: Honours
Supervisors: Prof Namita Roy Choudhury and Prof Naba Dutta

Description: Cyclodextrin (CD)s' are cyclic oligosaccharides molecules with six to eight glucose units linked via 1-4 linkage. A CD has a truncated shape with a cavity, which resembles a bottomless bucket. The central cavity is hydrophobic in nature. The primary hydroxyl groups are arranged at the narrow side of the torus and the secondary and tertiary hydroxyl groups at the wider side of the torus.

This unique structural feature makes CD an ideal host for complexation with various molecules (guest)1-3. Thus, there is enormous possibility to bind almost any guest species such as food component, flavour, drug, DNA, lipids, engineering materials etc. Such systems are currently under intense investigation due to their potential use in biomedical, pharmaceutical and waste water treatment applications. 

Our current work showed that such type of template could be effectively used as a carrier for controlled release system. Thus, the proposed project is aimed at investigating and optimising the incorporation of active molecules (such as antibacterial species) into CD.

In order to obtain enhanced guest binding, CD will be chemically modified and explored on their complexation behavior. Upon complexing, the physicochemical properties of the host-guest system will be evaluated by spectroscopic, and microscopic methods followed by antibacterial testing. 

References
1) CD and their application as chemosensors, John Luong, Chemosensors of ion and molecule recognition, 1997, 492.
2) U. Denter, H.J. Buschmann, D. Knittel and E. Schollmeyer, Angew. Makromol. Chem., 153-163, 248, 1997.
3) T. Cserhati and E. Forgacs, Eur. J. Pharm. Biopharm, 153, 46 (2), 1998.

Areas of study and research

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